Forskning

Publications: 

A randomized study comparing plasma concentration of ropivacaine after local infiltration analgesia and femoral block in primary total knee arthroplasty. Affas F, Stiller CO, Nygårds EB, Stephanson N, Wretenberg P, Olofsson C. Scand J Pain. 2012 Jan 1;3(1):46-51. 

Intrathecal analgesia by bupivacaine is not enhanced by coadministration of morphine in patients with severe cancer-related pain: a randomized double-blind cross-over study.

Reif I, Wincent A, Stiller CO. Int J Clin Pharmacol Ther. 2017 Jun;55(6):525-532. 

Adverse Drug Reactions in a Tertiary Care Emergency Medicine Ward - Prevalence, Preventability and Reporting. Rydberg DM, Holm L, Engqvist I, Fryckstedt J, Lindh JD, Stiller CO, Asker-Hagelberg C.

PLoS One. 2016 Sep 13;11(9):e0162948.

Long-term pattern of opioid prescriptions after femoral shaft fractures. Al Dabbagh Z, Jansson KÅ, Stiller CO, Montgomery S, Weiss RJ. Acta Anaesthesiol Scand. 2016 May;60(5):634-41.

Plasma levels of levobupivacaine during continuous infusion via a wound catheter after major surgery in newborn infants: An observational study. Krylborn J, Anell-Olofsson ME, Bitkover C, Lundeberg S, Bartocci M, Stiller CO, Larsson BA. Eur J Anaesthesiol. 2015 Dec;32(12):851-6. 

Which Medication Is the Patient Taking at Admission to the Emergency Ward? Still Unclear Despite the Swedish Prescribed Drug Register. Engqvist I, Wyss K, Asker-Hagelberg C, Bergman U, Odar-Cederlöf I, Stiller CO, Fryckstedt J. PLoS One. 2015 Jun 12;10(6):e0128716. 

Plasma concentration of ketorolac after local infiltration analgesia in hip arthroplasty. Affas F, Eksborg S, Wretenberg P, Olofsson C, Stephanson N, Stiller CO. Acta Anaesthesiol Scand. 2014 Oct;58(9):1140-5.

Ropivacaine pharmacokinetics after local infiltration analgesia in hip arthroplasty. Affas F, Eksborg S, Wretenberg P, Olofsson C, Stiller CO. Anesth Analg. 2014 Oct;119(4):996-9. 

No signs of dose escalations of potent opioids prescribed after tibial shaft fractures: a study of Swedish National Registries. Al Dabbagh Z, Jansson KÅ, Stiller CO, Montgomery S, Weiss RJ. BMC Anesthesiol. 2014 Jan 13;14:4.

Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons. Taylor BK, Fu W, Kuphal KE, Stiller CO, Winter MK, Chen W, Corder GF, Urban JH, McCarson KE, Marvizon JC. Neuroscience. 2014 Jan 3;256:178-94. 

Pharmacokinetics after a single intravenous dose of the opioid ketobemidone in neonates. Lundeberg S, Stephanson N, Stiller CO, Eksborg S. Acta Anaesthesiol Scand. 2012 Sep;56(8):1026-31.

The value of preoperative grade of radiographic and histological changes in predicting pain relief after total knee arthroplasty for osteoarthritis. Lundblad H, Kreicbergs A, Söderlund V, Ulfgren AK, Stiller CO, Jansson KÅ. Knee Surg Sports Traumatol Arthrosc. 2012 Sep;20(9):1815-21.

Pain control after total knee arthroplasty: a randomized trial comparing local infiltration anesthesia and continuous femoral block. Affas F, Nygårds EB, Stiller CO, Wretenberg P, Olofsson C. Acta Orthop. 2011 Aug;82(4):441-7.

Harmonisation of ethics committees' practice in 10 European countries. Hernandez R, Cooney M, Dualé C, Gálvez M, Gaynor S, Kardos G, Kubiak C, Mihaylov S, Pleiner J, Ruberto G, Sanz N, Skoog M, Souri P, Stiller CO, Strenge-Hesse A, Vas A, Winter D, Carné X. J Med Ethics. 2009 Nov;35(11):696-700.

Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in children. Lundeberg S, Stephanson N, Lafolie P, Olsson GL, Stiller CO, Eksborg S. Acta Anaesthesiol Scand. 2010 Apr;54(4):435-41.

Maternal use of thyroid hormones in pregnancy and neonatal outcome. Wikner BN, Sparre LS, Stiller CO, Källén B, Asker C. Acta Obstet Gynecol Scand. 2008;87(6):617-27.

Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: neonatal outcome and congenital malformations. Wikner BN, Stiller CO, Bergman U, Asker C, Källén B. Pharmacoepidemiol Drug Saf. 2007 Nov;16(11):1203-10.

Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: maternal characteristics. Wikner BN, Stiller CO, Källén B, Asker C. Pharmacoepidemiol Drug Saf. 2007 Sep;16(9):988-94.

The addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplasty. Stiller CO, Lundblad H, Weidenhielm L, Tullberg T, Grantinger B, Lafolie P, Jansson KA. Acta Anaesthesiol Scand. 2007 Mar;51(3):322-30.

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. J Neurosci. 2005 Jan 12;25(2):409-16.

Capsaicin-evoked substance P release in rat dorsal horn increases after peripheral inflammation: a microdialysis study. Warsame Afrah A, Gustafsson H, Olgart L, Brodin E, Stiller CO, Taylor BK. Neurosci Lett. 2004 Sep 23;368(2):226-30.

Stimulation of spinal 5-HT(2A/2C) receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn. Kjørsvik Bertelsen A, Warsame Afrah A, Gustafsson H, Tjølsen A, Hole K, Stiller CO. Brain Res. 2003 Oct 10;987(1):10-6.

Microdialysis in pain research. Stiller CO, Taylor BK, Linderoth B, Gustafsson H, Warsame Afrah A, Brodin E. Adv Drug Deliv Rev. 2003 Aug 28;55(8):1065-79. Review.

Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. Gustafsson H, Flood K, Berge OG, Brodin E, Olgart L, Stiller CO. Exp Neurol. 2003 Aug;182(2):427-34.

Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons.

Afrah AW, Fiskå A, Gjerstad J, Gustafsson H, Tjølsen A, Olgart L, Stiller CO, Hole K, Brodin E. Pain. 2002 Mar;96(1-2):49-55.

Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn. Afrah AW, Stiller CO, Olgart L, Brodin E, Gustafsson H. Neurosci Lett. 2001 Dec;316(2):83-6.

Morphine-induced in vivo release of spinal cholecystokinin is mediated by delta-opioid receptors--effect of peripheral axotomy. Gustafsson H, Afrah AW, Stiller CO. J Neurochem. 2001 Jul;78(1):55-63.

Changes in spinal cholecystokinin release after peripheral axotomy. Afrah AW, Gustafsson H, Olgart L, Brodin E, Stiller CO. Neuroreport. 2001 Jan 22;12(1):49-52.

Peripheral axotomy increases cholecystokinin release in the rat anterior cingulate cortex. Gustafsson H, Stiller CO, Brodin E. Neuroreport. 2000 Oct 20;11(15):3345-8.

Pharmacological characterization of morphine-induced in vivo release of cholecystokinin in rat dorsal horn: effects of ion channel blockers. Gustafsson H, Afrah A, Brodin E, Stiller CO. J Neurochem. 1999 Sep;73(3):1145-54.

Measurement of cholecystokinin release in vivo in the rat spinal dorsal horn. Gustafsson H, de Araujo Lucas G, Schött E, Stiller CO, Alster P, Wiesenfeld-Hallin Z, Brodin E. Brain Res Brain Res Protoc. 1999 Jul;4(2):192-200.

Peripheral axotomy influences the in vivo release of cholecystokinin in the spinal cord dorsal horn-possible involvement of cholecystokinin-B receptors.  Gustafsson H, de Araújo Lucas G, Schött E, Stiller CO, Alster P, Wiesenfeld-Hallin Z, Brodin E. Brain Res. 1998 Apr 20;790(1-2):141-50.

Opioid-induced release of neurotensin in the periaqueductal gray matter of freely moving rats.

Stiller CO, Gustafsson H, Fried K, Brodin E. Brain Res. 1997 Nov 7;774(1-2):149-58.

Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy. Meyerson BA, Cui JG, Yakhnitsa V, Sollevi A, Segerdahl M, Stiller CO, O'Connor WT, Linderoth B. Stereotact Funct Neurosurg. 1997;68(1-4 Pt 1):129-40.

Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Stiller CO, Cui JG, O'Connor WT, Brodin E, Meyerson BA, Linderoth B. Neurosurgery. 1996 Aug;39(2):367-74; discussion 374-5.

Local administration of morphine decreases the extracellular level of GABA in the periaqueductal gray matter of freely moving rats. Stiller CO, Bergquist J, Beck O, Ekman R, Brodin E. 

Neurosci Lett. 1996 May 17;209(3):165-8.

Capillary electrophoresis with laser-induced fluorescence detection: a sensitive method for monitoring extracellular concentrations of amino acids in the periaqueductal grey matter. Bergquist J, Vona MJ, Stiller CO, O'Connor WT, Falkenberg T, Ekman R. J Neurosci Methods. 1996 Mar;65(1):33-42.

Repeated spinal cord stimulation decreases the extracellular level of gamma-aminobutyric acid in the periaqueductal gray matter of freely moving rats. Stiller CO, Linderoth B, O'Connor WT, Franck J, Falkenberg T, Ungerstedt U, Brodin E. Brain Res. 1995 Nov 20;699(2):231-41.

Gamma-aminobutyric acid is released in the dorsal horn by electrical spinal cord stimulation: an in vivo microdialysis study in the rat. Linderoth B, Stiller CO, Gunasekera L, O'Connor WT, Ungerstedt U, Brodin E.

Neurosurgery. 1994 Mar;34(3):484-8; discussion 488-9.

An animal model for the study of brain transmittor release in response to spinal cord stimulation in the awake, freely moving rat: preliminary results from the periaqueductal grey matter. Linderoth B, Stiller CO, O'Connor WT, Hammarström G, Ungerstedt U, Brodin E. Acta Neurochir Suppl (Wien). 1993;58:156-60.

Release of neurotransmitters in the CNS by spinal cord stimulation: survey of present state of knowledge and recent experimental studies. Linderoth B, Stiller CO, Gunasekera L, O'Connor WT, Franck J, Gazelius B, Brodin E. Stereotact Funct Neurosurg. 1993;61(4):157-70.

The adenosine analogue R-PIA interacts with substance P binding in rat brain and spinal cord.

Stiller CO, Fastbom J, Fredholm BB, Brodin E. Acta Physiol Scand. 1991 Apr;141(4):573-4.

Repeated electroconvulsive shock increases tachykinin and cholecystokinin mRNA expression in ventral periaqueductal gray. Lindefors N, Brodin K, Stiller CO, Persson H, Brodin E. Neuroscience. 1991;45(1):73-80.